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KMID : 1134820150440091249
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Journal of the Korean Society of Food Science and Nutrition
2015 Volume.44 No. 9 p.1249 ~ p.1255
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Bioavailability of Organic Selenium in Selenium-Deficient Rats
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Jung Eun-Young
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Abstract
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We examined the effects of selenium-binding peptide from sericin hydrolysates on the bioavailability of selenium-deficient rats. Three-week-old male rats were fed a selenium-deficient diet for 4 weeks while the normal control group was fed a normal diet. The selenium-deficient rats were divided into three groups: no treatment, organic selenium (OS), and inorganic selenium (IS). After selenium supplementation for 4 weeks, the level of serum glutathione reduced form in rats treated with organic selenium was significantly higher than that of inorganic selenium. Selenium retention rate also increased significantly in the organic selenium group compared to the inorganic selenium group [selenium deficient diet (DD)+OS 50.25% vs. DD+IS 17.04%, P<0.05]. In conclusion, binding of selenium to peptides from sericin hydrolysates seems to improve its bioavailability, and can hasten a cure for selenium deficiency in experimental rats.
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KEYWORD
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bioavailability, organic selenium, sericin, selenium deficient diet
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